For example, single-cell transcriptomic analyses of brain samples taken from Setd5+/− and Ankrd11Yoda mice or behavioral and biochemical examination of mice with conditional knockout of Setd5 or Ankrd11 would be helpful to determine which cell types require SETD5 for preventing the pathogenesis of NDD/KBG syndrome. Here, SETD5 is linked to KBG syndrome.