SETD5 and cancer: Whereas an increase in SETD5 expression or activity may ameliorate the symptoms of IDD23, the effect of such an increase on tumorigenesis will need to be determined, given that SETD5 is upregulated in most cancer types (Ding et al., 2019; Yu et al., 2019; Zhang et al., 2019; Piao et al., 2020; Wang et al., 2020; Chen et al., 2021; Yang et al., 2021; Jiang, et al., 2022; Park et al., 2022; Yang et al., 2022).