Zhu et al. (2018) showed knockout lncRNA UCA1 in SKBR-3 breast cancer cell, resulting in trastuzumab sensitivity via lncRNA UCA1/miR-18a/YAP1 axis (Zhu et al., 2018). High expression of lncRNA HOTAIR in SK-BR-3-TR trastuzumab-resistant breast cancer cell line induced EMT confirmed by dysregulation of marker i.e., TGF-β, Snail, Vimentin, and E-cadherin (Chen et al., 2019). This evidence concerns the gene HOTAIR and breast cancer.