The results of Liang et al. (2018b) revealed that lncRNA-PRLB could regulate the chemoresistance in breast cancer via modulating the expression of miR-4766-5p and SIRT1 (Sirtuin 1) genes (Liang et al., 2018b) Higher expression levels of RHPN1-AS1 were measured by RNA FISH (fluorescent in situ hybridization) and Western blot assays in MCF-7 and MDA-MB-231 breast cancer cell. The gene discussed is SIRT1; the disease is breast cancer.