Previous research (Bustos-Moran et al., 2019; Sun et al., 2021; Long and Zhang, 2022) has shown that AURKA may impact T cells, reshape the immunosuppressive tumor microenvironment, apoptosis, and hypoxia and hence contribute to immunological control, particularly CD8+ T cells that govern Th1 regulation. The gene discussed is CD8A; the disease is neoplasm.