CD274 and neoplasm: While it is true, recent advances have revealed multiple molecular mechanism as a prevalent tumor therapy, such as CD24/Siglec-10, EMT, PD-L1/PD-1, C/EBPβ transcription factors and hypoxia/HIF-1α (Marigo et al., 2010; Vaupel and Multhoff, 2018; Jiang et al., 2019; Jiang and Zhan, 2020; Yin and Gao, 2020).