On the one hand, it was revealed by some studies that up-regulated CXCL13 expression could promote the proliferation, migration and invasion of CRC cells (Zhu et al., 2015), and was responsible for the dismal survival and drug resistance for CRC patients (Qi et al., 2014; Zhang et al., 2020). The gene discussed is CXCL13; the disease is colorectal carcinoma.