IL22 and neoplasm: Other tumor-promoting effects of γδT cells include inhibiting the maturation of DCs, the senescent DCs can further suppress CD4+T cells and CD8+T cells (Peng et al., 2007; Ye et al., 2013a; Ye et al., 2013b), inhibiting T cell responses by secreting galectin and expressing programmed cell death protein ligand 1 (PDL1); and inducing tumor cell proliferation by expressing IL-22 and biregulin (Daley et al., 2016; Khosravi et al., 2018; Chen et al., 2019; Silva-Santos et al., 2019; Zhang et al., 2020).