The activated γδT cells release perforin and granzyme B to secrete cytokines IFN-γ, TNF-α, as well as TRAIL, Fas/FasL and many other ways to exert an effect on colon cancer cells (Todaro et al., 2009; Wu et al., 2014a). The gene discussed is PRF1; the disease is malignant colon neoplasm.