SDHB and cancer: For example, it has been described that inactivating mutations in SDH complex suppress its activity, resulting in the accumulation of succinate, an oncometabolite that generates a pseudohypoxic phenotype and contributes to cancer, and that the biological effect of knocking down the SDHB gene is associated with a positive effect on cell proliferation, which is related to increased chromaffin cell metabolism and their adaptation to glutamine use as an alternative source of energy, thus promoting the activity of the oxidative phosphorylation system (Tabebi et al., 2022).