KISS1 and hypogonadism: Four mosaic pigs with elevated KISS1-disruptive allele frequencies (>90%), displayed typical phenotypes of individuals with non-functional KISS1; hypogonadotropism, hypogonadism, failure to achieve puberty, and lack of gamete production (d’Anglemont et al., 2007; Lapatto et al., 2007; Uenoyama et al., 2015; Ikegami et al., 2020).