On the other hand, Go Germ Cell Proliferation, KEGG MAPK Signaling Pathway, KEGG P53 Signaling Pathway, Wp Activation Of Nlrp3 Inflammasome By Sarscov2, Wp Ras And Bradykinin Pathways In COVID-19, Wp Ras Signaling, Wp Complement Activation, Wp Human Complement System, Go Senescence were negatively correlated with pyruvate metabolism in both Control and COVID-19 groups (Figures 5G, H), which proved that cell cycle damage was significantly negatively correlated with normal pyruvate metabolism. The gene discussed is KNG1; the disease is COVID-19.