HIF-1, NF-κB, IL-17, EGFR, MAPK, endocrine resistance, tyrosine kinase resistance, platinum drug resistance, antifolate resistance, arginine biosynthesis, sphingolipid, human cytomegalovirus infection, Kaposi’s sarcoma, small cell lung cancer etc. The gene discussed is NFKB1; the disease is small cell lung carcinoma.