Among the top 20 most negatively correlated pathways in the pyruvate metabolic pathway, KEGG Glycosaminoglycan Degradation, KEGG Type II Diabetes Mellitus, KEGG Adherens Junction, KEGG Oocyte Meiosis, Wp Ras Signaling Pathway, KEGG mTOR Signaling Pathway showed a significant negative correlation (Figure 5D). The gene discussed is MTOR; the disease is diabetes mellitus.