Interestingly, several genes implicated in cell senescence are among the top 20 genes negatively correlated with STAR or CYP11A1 respectively, especially SRSF1, NIPBL expression changed dramatically during COVID-19, suggesting that SRSF1, NIPBL may be important in suppressing androgen synthesis during COVID-19-induced senescence Figure 4K. This evidence concerns the gene CYP11A1 and COVID-19.