SRSF1, NIPBL, the hub genes negatively correlated with essential enzymes in androgen synthesis, have been implicated in the process of cellular senescence in earlier research (Blanco and Bernabéu, 2012; Gu et al., 2021), demonstrating the importance of cellular senescence in COVID-19-induced androgen synthesis suppression. This evidence concerns the gene SRSF1 and COVID-19.