In another experiment, we identified three specific genes associated with the prognostic signature: TCN1, DIRAS3, and IZUMO4. A prognostic model for lung adenocarcinoma based on eight genes (TCN1, COL1A1, SPOK2, PCP4, S100P, CAV2, GPX3, and ASPM) has been previously constructed (Tu et al., 2021). This evidence concerns the gene GPX3 and lung adenocarcinoma.