Additionally, ALC1 (amplification in liver cancer-1) plays an important role in metastasis and invasion of BC, and poly(ADP-ribosyl)ated PARP1 stimulated ALC1 at DNA damage sites, emphasizing that the PBZ sphere of CHFR and PMD and Macro spheres of ALC1 are essential for the PAR interface. The gene discussed is PARP1; the disease is breast cancer.