The upregulation of NLRC4 activated the intestinal immune network for IgA production, primary immunodeficiency, and aminoacyl tRNA biosynthesis, whereas the downregulation of NLRC4 activated folate biosynthesis, complement and coagulation cascades, and glycosphingolipid biosynthesis lacto and neolacto series. The gene discussed is CD79A; the disease is inborn error of immunity.