We found DE mRNAs related to reactive oxygen species (ROS) and reactive nitrogen species (RNS) production in phagocytes, such as Neutrophil NADPH Oxidase Factor 1 and 2 (NCF1 or p47phox and NCF2 or p67phox) and ATPase H + Transporting V1 Subunits B2, C1, D, F, H (ATP6V1), and detoxification of ROS, as thioredoxin (TXN), superoxide dismutase 2 (SOD2), Glutathione-Disulfide Reductase (GSR), Glutathione Peroxidase 3 (GPX3), and Peroxiredoxin 1 (PRDX1), in infection by all the three Leishmania species (Figures 3A,B, Supplementary Table S2). Here, SOD2 is linked to infection.