Moreover, genes CBX3, NAP1L1, EIF4B, PLS3, MRFAP1, GPATCH8, TENM3, BAZ2A, AMMECR1, JAZF1, PIM3, DNA2, GTPBP1, ITGB3, DDI2 are localized in myopia/HM loci. Furthermore, mutations in DCBLD2, GNAS, CTNNB1, BZW1, ACTN4, LIMCH1, FKBP1B, VAV2, ENKD1, ITGB3 cause abnormal murine eye phenotype (MGI:1920629, MGI:95777, MGI:88276, MGI:1914132, MGI:1890773, MGI:1924819, MGI:1336205, MGI:102718, MGI:2142593, MGI:96612). The gene discussed is GNAS; the disease is myopia.