TGM3 is either down- or upregulated in various cancers, including oral cancer, laryngeal cancer, esophageal cancer, colorectal cancer and hepatocellular cancer (Chen et al., 2000; Mendez et al., 2007; Negishi et al., 2010; Liu et al., 2012; Nayak et al., 2019; Smirnov et al., 2019; Hu et al., 2020). The gene discussed is TGM3; the disease is hepatocellular carcinoma.