Recently, emerging studies have reported various clinical value and physiological function correlations between TGM3 and various cancers, including clinical stage, prognosis, tumor heterogeneity, gene mutation, methylation level, lymphocyte infiltration and immune regulation, etc. Many studies have revealed that the alternation of TGM3 expression level is significantly correlated with cell proliferation, dedifferentiation, migration, invasiveness, high incidence of lymph node metastasis, high incidence rate of recurrence and low survival rate (Smirnov et al., 2019; Hu et al., 2020). The gene discussed is TGM3; the disease is metastatic malignant neoplasm in the lymph nodes.