Inositol-trisphosphate 3-kinase A (ITPKA) is ectopically expressed in several human cancers in addition to neurons of the central nervous system and duodenum, which is important in controlling calcium signaling pathway and actin dynamics, and it may provide new options for treatment for patients (Blechner et al., 2020), such as testis, thyroid, lung, pancreas, breast, prostate, colon, liver and breast cancer so on (Windhorst et al., 2017). The gene discussed is ITPKA; the disease is cancer.