Subfamily 1 of the Cytochrome P450 family Cytochrome P450 enzymes (P450s or CYPs), a unique family of heme proteins containing ferrous ion (Fe2+) and functioning as oxygenases, are linked to the pathogenesis of several diseases, including primary congenital glaucoma (buphthalmos), inflammatory disease, and cancers (Kwon et al., 2021). This evidence concerns the gene PROS1 and cancer.