PROS1 and primary congenital glaucoma: Subfamily 1 of the Cytochrome P450 family Cytochrome P450 enzymes (P450s or CYPs), a unique family of heme proteins containing ferrous ion (Fe2+) and functioning as oxygenases, are linked to the pathogenesis of several diseases, including primary congenital glaucoma (buphthalmos), inflammatory disease, and cancers (Kwon et al., 2021).