Elsewhere (Ueta et al., 2021b), we reported that plasma miR-628-3p was significantly up-regulated in AD-ACD+ with giant papillae, suggesting that its plasma level represents a marker to predict severe ACD in AD patients and that the hsa-miR-628-3p mimic down-regulated PAMPs such as TLR3, RIG-I, and MDA5 and 19 genes (STAP1, IFI44L, CXCL11, TNFSF10, AIM2, RSAD2, IFITM1, CXCL10, CCL8, TRIM22, HERC5, IFI27, IFIT2, GBP4, IFIT1, IDO1, HESX1, TNFSF13B, and USP41). This evidence concerns the gene HESX1 and Alzheimer disease.