We also reported that TLR3 regulated allergic reactions such as allergic conjunctivitis (Ueta et al., 2009) and contact and atopic dermatitis (Nakamura et al., 2015; Yasuike et al., 2017), because these allergic reactions were reduced in TLR3 knock-out mice. The gene discussed is TLR3; the disease is atopic conjunctivitis.