Elsewhere (Ueta et al., 2021b), we reported that plasma miR-628-3p was significantly up-regulated in AD-ACD+ with giant papillae, suggesting that its plasma level represents a marker to predict severe ACD in AD patients and that the hsa-miR-628-3p mimic down-regulated PAMPs such as TLR3, RIG-I, and MDA5 and 19 genes (STAP1, IFI44L, CXCL11, TNFSF10, AIM2, RSAD2, IFITM1, CXCL10, CCL8, TRIM22, HERC5, IFI27, IFIT2, GBP4, IFIT1, IDO1, HESX1, TNFSF13B, and USP41). The gene discussed is TLR3; the disease is Alzheimer disease.