Meanwhile, the CX3CL1/CX3CR1 coding region was found to have SNPs with various amino acid substitutions, such as the T280M SNP and V249I SNP, which would affect their expression, function and activity and may cause platinum resistance in ovarian cancer patients (Erreni et al., 2016; Yao et al., 2014). Here, CX3CR1 is linked to ovarian carcinoma.