POLE and cancer: In addation, CAT (Galasso et al., 2021), POLE (Bellido et al., 2016), NTHL1 (Magrin et al., 2021), ATP7B (Li et al., 2017), ISCA2 (Weiler et al., 2020; Green et al., 2022), NDUFA1 (Mamelak et al., 2005) and NDUFB2(Shan et al., 2020) have also been reported to play a key role in the development of cancers.