Previous study reported that POLE p. L424V mutation was more frequent in patients with polyposis, colorectal cancer and oligodendroglioma, and four POLD1 variants (p.D316H, p. D316G, p. R409W, and p. L474P) were identified in non-polyposis colorectal cancer families. The gene discussed is POLD1; the disease is colorectal cancer.