Previous study reported that POLE p. L424V mutation was more frequent in patients with polyposis, colorectal cancer and oligodendroglioma, and four POLD1 variants (p.D316H, p. D316G, p. R409W, and p. L474P) were identified in non-polyposis colorectal cancer families. Here, POLD1 is linked to oligodendroglioma.