For gene level analysis of differential methylation associated with MS in our patient cohort, we focused on the top 10 DMR’s: ARID5B, BAZ2B, SFRP2, WBP1L, CDK2AP1, CLU, CTSZ, RAB34, RABGAP1, and TNFSF12/TNFSF13. The gene discussed is CLU; the disease is myeloid sarcoma.