Based on the GO enrichment results, the four-lncRNAs signature might influence osteosarcoma by regulating the extracellular matrix and tumor microenvironment (Cohen et al., 2016; Zhou et al., 2016; Yan et al., 2018; Zheng et al., 2019), while the KEGG data suggested that MAPK and PI3K-Akt signaling may be important through their effects on cell proliferation, apoptosis, migration, and metastasis (Xiang et al., 2014; Li et al., 2015; Zi et al., 2015; Li et al., 2020b; Yang et al., 2020; Naz et al., 2021). This evidence concerns the gene AKT1 and neoplasm.