AKT1 and osteosarcoma: As two well-studied pathways, the MAPK and PI3K-Akt signaling pathways have been proved to play important roles in osteosarcoma, by regulating cell proliferation, apoptosis, migration, and metastasis (Cheng et al., 2017; Han et al., 2019; Zhang et al., 2020b; Zhang et al., 2020c).