By utilizing GEPIA2’s module “Pathological Stage Plot” to evaluate the relationship between CLU expression and the pathological staging of malignancies such as KICH, KIRC, LIHC, LUAD, Skin Cutaneous Melanoma (SKCM), THCA, and UCS (Figure 2D, all p < 0.05), excluding others (Supplementary Figure S3). This evidence concerns the gene CLU and cutaneous melanoma.