CLU and cervical squamous cell carcinoma: We discovered that the most common genetic alteration was CLU gene missense mutation and P234 L/S modification in the clusterin domain, which was identified among 300 SARC patients, 122 cases of SKCM, and 61 cases of CESC (Figure 4B), and is capable of inducing a missense mutation of the CLU gene, translation from P (proline) to L (leucine) at the 234 sites of CLU protein.