Shi et al. (2021) have found that CDC20 stabilizes HIF-1A protein under normoxic conditions in liver cancer tissues, and depletion of CDC20 leads to tumor growth retardation and inactivation of the HIF-1A signaling pathway. These studies indicate that CDC20 is a key role in the link of the malignant progression of liver cancer, which is consistent with our previous prediction. The gene discussed is CDC20; the disease is liver cancer.