Tian et al. (2018) found that the incidence of microvascular infiltration in patients with CDCA5 overexpression (45.90%) was higher than that in patients with low CDCA5 expression (21.92%) in liver cancer. Both in vivo and in vitro experiments suggested that CDCA5 inhibition led to a reduced cell-proliferation rate, advocating that CDCA5 is involved in the malignant progression of HCC. The gene discussed is CDCA5; the disease is liver cancer.