Recent reports have shown that aurora kinase A (AURKA), IL6R, NUPR1, and DICER1 play important role in the development, progression, and metastasis of a variety of cancers including colon cancer (Iliou et al., 2014; Wang et al., 2020; Luan et al., 2021; Martin et al., 2021; Mou et al., 2021; Kahl et al., 2022). This evidence concerns the gene NUPR1 and malignant colon neoplasm.