SERPINE1 could induce angiogenesis and tumor inflammatory microenvironment, in which anoikis was a critical player, by regulating the expression level of VEGF and IL-6 via VEGF and JAK-STAT3 inflammatory pathways (Sakamoto and Kyprianou, 2010; Feng et al., 2014; Teng et al., 2021; Chen et al., 2022). Here, IL6 is linked to neoplasm.