According to the regression analysis result, an ARGPS model was established as follows: ARGPS = 0.116 ✕ PDK4 exp + (−0.340) ✕ EZH2 exp +0.297 ✕ NOX4 exp +0.108 ✕ MMP11 exp +0.247 ✕ SERPINE1 exp + (−0.412) ✕ DNMT1 exp +0.243 ✕ SNCG exp. Based on the median ARGPS, GC patients of the TCGA cohort were classified into the high- and low-risk groups. This evidence concerns the gene SERPINE1 and gastric cancer.