Familial focal epilepsy with variable foci (FFEVF) is considered one of the most common forms of autosomal dominant epilepsy caused by mutations in the DEP domain containing 5 (DEPDC5), NPR2 like (NPRL2), and NPR3 like (NPRL3) (Dibbens et al., 2013; Ricos et al., 2016). Here, DEPDC5 is linked to focal epilepsy.