S1PR4 and neoplasm: According to the expression levels and regression coefficients, the downregulated BAX, PWP2, SERTAD1, S1PR4, ZFAND1, NUDT13 and ZNF107 with HR < 1 were considered as tumor suppressors, whereas the MVD, BAD, CPNE7, CPNE7, UTP23 and ZNF124 upregulated with HR > 1 were regarded as oncogenes (Supplementary Figure S2).