The SNP rs12474050 (sex-biased differential association p = 1.8e-4) is a cis-eQTL of SPEG and emerged with suggestive association with severe COVID-19 in women (p = 1.8e-4; beta = 0.36; se = 0.10) but not in men (p = 0.23; beta = –0.08; se = 0.07) (Figure 1). Here, SPEG is linked to COVID-19.