SPEG and COVID-19: It turned out that the strategy is more robust, as more significant upregulation of SPEG in cardiomyocyte was observed in COVID females (0.29 percent of cardiomyocytes expression SPEG) than in COVID-19 males (0.22 percent of cardiomyocytes expression SPEG) (differential expression p-value = 5.0e-18 and fold change = 1.2; see Figure 4H; Supplementary Figure S1).