As SARS-CoV-2 infection could damage the cardiac tissue both directly and indirectly (Topol, 2020; Saeed et al., 2021), the upregulation of SPEG, partially increased in higher magnitude in female cardiomyocytes, would be a potentially compensatory response and self-cardioprotective action due to the infection of SARS-CoV-2 in heart. The gene discussed is SPEG; the disease is infection.