SPEG and Hypertension: As rs12474050 was reported as a cis-eQTL of SPEG by the previously published hypertension GWAS (Evangelou et al., 2018), in which the GTEx database V7 was used to annotate these cis-eQTLs, we further evaluated its association with SPEG expression across 49 tissues in GTEx database V8 (GTEx, 2020).