The potential cause of Post-COVID-19 hypertension by SARS-CoV-2 infection may be due to the shift of renin-angiotensin system (RAS) related balance from Mas [angiotensin converting enzyme 2 (ACE2)/angiotensin (Ang) 1-7/Mas] axis to RAS [Ang converting enzyme (ACE)/Ang II/Ang II type I receptor (AT1R)] axis (Uysal et al., 2022) upon SARS-CoV-2 infection. The gene discussed is ACE2; the disease is hypertensive disorder.