MIS12 and cancer: At the same time, we can see, in the database identified molecules that are associated with KNL1 height mostly for SAC related gene (BUB1 BUB1R, SPC25, MIS12, NDC80, ZWINT), The highly related genes co-up-regulated with KNL1 in PRAD samples (KIF14, ASPM, CKAP2L) are also involved in spindle assembly regulation and microtubule formation, and their high expression has been reported to be associated with the occurrence and development of a variety of cancers (Pai et al., 2019; Yang et al., 2019; Monteverde et al., 2021).