In Brazilian early-onset breast cancer patients (age ≤35 years) cohort, the frequency of germline mutations in BRCA1/2 with luminal tumors is reported to be 16% (Encinas et al., 2018), and 43% of luminal non-BRCA1/2 mutant tumors harbored pathogenic variants in DNA repair genes (ATR, BAP1, ERCC6, FANCD2, FANCL, MLH1, MUTYH, PALB2, POLD1, POLE, RAD9A, RAD51 and TP53), whereas 54% had pathogenic variants in transcription-related genes. The gene discussed is TP53; the disease is breast cancer.