The overexpression of SHH is important for idealizing the tumor microenvironment for metastasis and progression, whereas the overexpression of GLI1 leads to the overexpression of matrix metalloprotease-1 (MMP-1) and vascular endothelial growth factor A (VEGFA), increasing the tumors’ metastatic potential (O’Toole et al., 2011; Kuehn et al., 2021). The gene discussed is VEGFA; the disease is neoplasm.