NFKB1 and familial pancreatic carcinoma: Finally, the blockage of NF-κB pathway using NF-κB inhibitor inhibited colonies formed in soft agar (Figure 5(d)), BrdU positive cells (Figure 5(e)), and invaded cells (Figure 5(f)) of SPRR3-overexpressing cells, suggesting that activation of NF-κB is essential for SPRR3 regulating aggressiveness of pancreatic cancer cells.