Consistently, the mRNA (Figure 1(d)) and protein expression (Figure 1(f)) of SPRR3 were markedly higher in pancreatic cancer cell lines AsPC-1, CFPAC-1, PANC-1, BxPC-3, Capan-1, Capan-2, Hs 766 T, and MIN6 than in normal human pancreatic ductal epithelial cells (HPDECs). The gene discussed is SPRR3; the disease is familial pancreatic carcinoma.