Peptide-O-linked mannose beta-1,2-N-acetylglucosaminyltransferase 1 (PomGnT1) regulates progression of glioma by activating the beta-catenin pathway and could work as a factor in the prognosis and treatment of glioma as well as a neotherapeutic molecular target. Here, POMGNT1 is linked to central nervous system cancer.