IL4 and asthma: In fact, the level of Th1 cytokines IL-12 and IFN-ɣ as well level of Treg cytokine IL-10 in lung of asthma mice was lower than control, and inversely, Th2 cells response-associated the cytokines IL-4, IL-5, and IL-13 had a significant increase in lung of asthma mice compared to the control group.