However, the main features of allergic asthma were reproduced, such as increased mast cell population, elevated IgE levels, pulmonary eosinophilia, exacerbated mucus secretion and exaggerated collagen deposition, and pro-inflammatory cytokine storm associated with Th2 response accompanied by failure in cytokine secretion associated with the Th1 response. Here, IGHE is linked to allergic asthma.