Cancer susceptibility candidate 11 (CASC11) was found to stabilize E2F transcription factor 1 (E2F1) mRNA by recruiting eukaryotic translation initiation factor 4A3 (EIF4A3), which in turn affects the activation of NF-KB signaling pathway and Pl3K/AKT/mTOR pathway, and further regulated PD-L1 expression (145). The gene discussed is E2F1; the disease is cancer.