As previously described, we found that Tph cells in oligo JIA SF co-express HLA-DR to a greater extent than CD4+PD-1intCXCR5- T cells; however, we found no significant difference in the frequency of HLA-DR+ Tph cells between ANA+ and ANA- patients (Figures 2D, E) (41). The gene discussed is CD4; the disease is juvenile idiopathic arthritis.