At the transcriptomic level, Tph cells from RA and oligo JIA have a mutual gene expression program characterized by upregulation of multiple genes associated with B cell help such as PDCD1, CXCL13, CD40LG, SH2D1A/SAP and BATF (9, 47, 50). This evidence concerns the gene SH2D1A and rheumatoid arthritis.