Figure 4J shows that each tumor region has its own transcriptional factor expression profile. NPM1, ENO1, and CTNNB1 are highly expressed in the invasive tumor, and ATF4, JUND, and MYC are highly expressed in the hypoxia group (Figure 4J). Surprisingly, HIF1A expression in the invasive tumor was higher than that in the hypoxic tumor (Figure 4J). This evidence concerns the gene ATF4 and neoplasm.