In an orthotopic murine neuroblastoma model, the administration of miR-186 enhances the cytotoxic potential of NK cells by suppressing the TGF-β1 signaling pathway through TGF-βR1/2, which led to the restoration of NKG2D and DNAM-1 expression on NK cells (46). This evidence concerns the gene TGFB1 and neuroblastoma.