There were no differences in the clustering patterns of memory lymphocytes (CD45RO+CD4+/CD8+) between FD and control (Figure 6F), however there were larger areas of activated cells (CD44+CD4+/CD8+) in FD (Figure 6G) similarly to our flow cytometry finding of increased in CD4+ effector lymphocytes in FD patients. The gene discussed is CD8A; the disease is Fabry disease.