On the other hand, a specific subset of T cells that emerges with obesity may be maintained through homeostatic proliferation because studies showed that during the physiological aging process, T cells are maintained through homeostatic proliferation triggered by homeostatic cytokines and MHC associated with self-peptides (123, 124) and we previously found that obesity accelerates T-cell senescence and that senescent T cells have similar characteristics to T cells created by homeostatic proliferation during aging (7). Here, HLA-C is linked to obesity due to melanocortin 4 receptor deficiency.