In response to ocular HSV-1 infection, pro-inflammatory cytokines including IL-1, IL-6 and chemokines including CCL2, CCL3, CCL5, CXCL1, CXCL2, CXCL9, and CXCL10 are produced rapidly following infection by resident cells and infiltrating leukocytes (23, 25, 75, 76). The gene discussed is CXCL2; the disease is infection.