CXCL16 and glioblastoma: More interestingly, we found novel hub genes from immunosuppressive modules could be the upstream regulators of a series of cytokines and chemokines such as C3, CXCL3, CXCL16, and CXCL2 in macrophages and microglia cell, which further interact with Treg and shape the immunosuppressive microenvironment of GBM.