IGHE and asthma: Most of childhood-onset asthma is driven by type 2 immune response, without sufficient regulation by type 1 (Th1 cells) and type 3 (RORγt+ Foxp3+ Treg) responses, and can be defined by the high level of immunoglobulins E (IgE) in the serum and eosinophilic airway inflammation (10, 11).