Vγ9δ2 T cells, a specific γδT cell subset mainly found in the blood, recognize members of the butyrophilin (BTN) family, namely BTN2A1, through the gamma chain of their Vγ9δ2TCR, and additionally require BTN3A1 expression on the tumor cells for full activation (15–17). Here, BTN2A1 is linked to neoplasm.