TNFSF10 and Thrombocytopenia: Although it has reported that FasL- and TRAIL-deficient mice develop fatal autoimmune thrombocytopenia (134), it can be explained that FasL- and TRAIL-deficient mice suffer from severe lymphoproliferative disease, dysregulation of lymphocyte homeostasis leads to antiplatelet IgM and IgG production, which results in thrombocytopenia (133).