Anti-LGI1 encephalitis patients have elevated neurofilament light chain protein, glial fibrillary acidic protein and chemokine ligand 13 levels and reduced Visinin-like protein 1, Synaptosomal Associated Protein-25 (SNAP-25) and neurogranin levels in the serumand CSF (17–21). Here, SNAP25 is linked to viral encephalitis.