An IFN-γ signature was enriched in pre-treated tumors; specifically, a high IFN-γ signature in CD8+ T cells correlated to positive response to the combined therapy This study sheds light on transcriptional dynamics at the single-cell level within GC during immunochemotherapy and provides new insights for the use of neoadjuvant ICB in GC. The gene discussed is IFNG; the disease is gastric cancer.