In order to further investigate the possible mechanism of PROS1 on the impact of tumor immune micro-environment, GSEA analysis was conducted which revealed that high expression of PROS1 was correlated tothe T cell antigen receptor pathway (Figure 6A), the PD-1 signal pathway (Figure 6B) and the immunotherapy mediated by programmed cell death protein 1 (PD-1) blockade (Figure 6C). The gene discussed is PDCD1; the disease is neoplasm.