ICAM1 and Atherosclerotic lesion: Furthermore, several studies have demonstrated that endothelial cells on arterial vessels can release CCL2 to upregulate the cell adhesion molecules like vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), P-selectin, and E-selectin, to trigger cell arrest and facilitate leukocyte immigration into atherosclerotic lesions (23).