ADAM28 and asthma: In order to assess ADAM28 expression in lung in mouse models mimicking acute to chronic features of asthma, mRNAs corresponding to total ADAM28, soluble form (referred to as Variant 4: Var4) and membrane-bound form (or Variant 1: Var1) were measured by RT-PCR after ST, IT and LT allergen exposure (Figures 2A–C).