APP and Alzheimer disease: While several studies in mouse models for AD have shown the relevance of the NAD(P)+/NAD(P)H homeostasis in the brain, especially in hippocampus and cortex (Ghosh et al., 2012; Dong and Brewer, 2019; Dong et al., 2019), few reports have been published on the role of the NAD(P)+/NAD(P)H homeostasis in the McGill-R-Thy1-APP rats.