SPI1 and Diarrhea: SPI1 encodes an ETS-domain transcription factor PU.1 that activates gene expression exclusively in hematopoietic cells, including myeloid and lymphoid cells, e.g., such as lymphocyte B cell development, and is involved in disease-like Inflammatory diarrhea, primary mediastinal B cell Lymphoma and pediatric T cell acute lymphoblastic leukemia (Seki et al., 2017; Rothenberg et al., 2019).